ABSTRACT
Yellow fever(YF) is a natural focal disease transmitted by infected mosquitoes,which had caused epidemic in some areas of Europe and America port city in the history,bringing great disaster to human society.Since 40s of last century,a series of derivative strain of 17D vaccines,providing lifelong protection,had been vaccinated a large population who are trave ling to or living in areas at risk for YF,which avoid the outbreak of the disease,appearing quiet state.Since the beginning of 1990s,the disease had outbreak successively in Africa,tropical American areas and its nations.The mortality was even more higher than Ebola happened in 3 countries in West Africa between 2014 and 2015.In 2016-2017the large outbreak in Angola,Congo and Brazil,has claimed thousands of lives.Yellow fever has never occurred in Asia until the introduction of 11 cases by jet travel from Angola to China,which attracted the attention of Chinese government.Yellow fever elimination initiative strategic plan for 2017 2026 was launched by WHO,mainly based on that 17D vaccine which is safe and effective to control the spread of this disease.The measures of controlling mosquitoes and vaccination programs,in particular putting great expectations for the latter,are the main measures for prevention the disease and achievement the goal of WHO elimination strategic plan.But strong guarantees of related countries and abiding by the provisions of the global quarantine regulations are also important.Therefore,this article reviews the historical and the recent epidemic outbreaks of yellow fever,vaccination and other prevention measures,hoping that the WHO elimination of the yellow fever epidemic strategy will achieve successfully in 2026.